1yb1 | pdb_00001yb1

Crystal structure of human 17-beta-hydroxysteroid dehydrogenase type XI

spinqualitylabelsall models 1yb1, resolution 1.95Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 1yb1 is a 2 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: AOI, CL, GOL, SO4 Gene: DHRS8 (HUMAN) Activity: 17-beta-estradiol 17-dehydrogenase, with EC number 1.1.1.62 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum Function [DHB11_HUMAN] Can convert androstan-3-alpha,17-beta-diol (3-alpha-diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione. Tumor-associated antigen in cutaneous T-cell lymphoma. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. See Also Hydroxysteroid dehydrogenase

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