2oxw | pdb_00002oxw
Human MMP-12 complexed with the peptide IAG
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| 2oxw, resolution 1.15Å | |||||||||||||
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| Ligands: | ZN and CA | ||||||||||||
| Gene: | MMP12, HME (Homo sapiens) | ||||||||||||
| Activity: | Macrophage elastase, with EC number 3.4.24.65 | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
Disease
Known diseases associated with this structure: Cardiomyopathy, dilated, 1G OMIM:[188840], Cardiomyopathy, familial hypertrophic OMIM:[188840], Muscular dystrophy, limb-girdle, type 2J OMIM:[188840], Myopathy, early-onset, with fatal cardiomyopathy OMIM:[188840], Myopathy, proximal, with early respiratory muscle involvement OMIM:[188840], Tibial muscular dystrophy, tardive OMIM:[188840]
About this Structure
2OXW is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Snapshots of the reaction mechanism of matrix metalloproteinases., Bertini I, Calderone V, Fragai M, Luchinat C, Maletta M, Yeo KJ, Angew Chem Int Ed Engl. 2006 Dec 4;45(47):7952-5. PMID:17096442
Page seeded by OCA on Sun Mar 23 15:35:41 2008
