Structural highlights
2g8x is a 2 chain structure with sequence from "bacillus_coli"_migula_1895 "bacillus coli" migula 1895. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Ligands: | CO3, DTT, PO4 |
| NonStd Res: | CXM |
| Related: | 2g8m, 2g86, 2g8a, 2g89, 2g8d, 2g8o |
| Gene: | ThyA ("Bacillus coli" Migula 1895) |
| Activity: | Thymidylate synthase, with EC number 2.1.1.45 |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum |
Function
[TYSY_ECOLI] Provides the sole de novo source of dTMP for DNA biosynthesis. This protein also binds to its mRNA thus repressing its own translation.
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
See Also
