1d32 | pdb_00001d32

DRUG-INDUCED DNA REPAIR: X-RAY STRUCTURE OF A DNA-DITERCALINIUM COMPLEX

spinqualitylabelsall models 1d32, resolution 1.70Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 1d32 is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: DIT Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum Publication Abstract from PubMed Ditercalinium is a synthetic anticancer drug that binds to DNA by bis-intercalation and activates DNA repair processes. In prokaryotes, noncovalent DNA-ditercalinium complexes are incorrectly recognized by the uvrABC repair system as covalent lesions on DNA. In eukaryotes, mitochondrial DNA is degraded by excess and futile DNA repair. Using x-ray crystallography, we have determined, to 1.7 A resolution, the three-dimensional structure of a complex of ditercalinium bound to the double-stranded DNA fragment [d(CGCG)]2. The DNA in the complex with ditercalinium is kinked (by 15 degrees) and severely unwound (by 36 degrees) with exceptionally wide major and minor grooves. Recognition of the DNA-ditercalinium complex by uvrABC in prokaryotes, and by mitochondrial DNA repair systems in eukaryotes, might be related to drug-induced distortion of the DNA helix. Drug-induced DNA repair: X-ray structure of a DNA-ditercalinium complex.,Gao Q, Williams LD, Egli M, Rabinovich D, Chen SL, Quigley GJ, Rich A Proc Natl Acad Sci U S A. 1991 Mar 15;88(6):2422-6. PMID:2006181 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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