2az2 | pdb_00002az2

Flock House virus B2-dsRNA Complex (P4122)

spinqualitylabelsall models 2az2, resolution 2.60Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 2az2 is a 4 chain structure with sequence from Fhv. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. NonStd Res: 5BU Related: 2az0 Gene: B2 (FHV) Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum Function [B2_FHV] Binds double-strand RNA (dsRNA) with high affinity. Suppresses the host RNA silencing-based antiviral response. Publication Abstract from PubMed As a counter-defense against antiviral RNA silencing during infection, the insect Flock House virus (FHV) expresses the silencing suppressor protein B2. Biochemical experiments show that B2 binds to double-stranded RNA (dsRNA) without regard to length and inhibits cleavage of dsRNA by Dicer in vitro. A cocrystal structure reveals that a B2 dimer forms a four-helix bundle that binds to one face of an A-form RNA duplex independently of sequence. These results suggest that B2 blocks both cleavage of the FHV genome by Dicer and incorporation of FHV small interfering RNAs into the RNA-induced silencing complex. Dual modes of RNA-silencing suppression by Flock House virus protein B2.,Chao JA, Lee JH, Chapados BR, Debler EW, Schneemann A, Williamson JR Nat Struct Mol Biol. 2005 Nov;12(11):952-7. PMID:16228003 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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