2lui | pdb_00002lui

Structure of the PICK PDZ domain in complex with the DAT C-terminal

spinqualitylabelsall models 2lui, 20 NMR models Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 2lui is a 1 chain structure with sequence from Buffalo rat. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance. Gene: Pick1, Prkcabp (Buffalo rat) Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum Function [PICK1_RAT] Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel.

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