3wmp | pdb_00003wmp

Crystal structure of SLL-2

spinqualitylabelsall models 3wmp, resolution 2.00Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3wmp is a 6 chain structure with sequence from Sinularia lochmodes. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: A2G, CL, GLA, MPD, NA, NAG Related: 3wmq Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum Publication Abstract from PubMed D-Galactose-binding lectin from the octocoral, Sinularia lochmodes (SLL-2), distributes densely on the cell surface of microalgae, Symbiodinium sp., an endosymbiotic dinoflagellate of the coral, and is also shown to be a chemical cue that transforms dinoflagellate into a non-motile (coccoid) symbiotic state. SLL-2 binds with high affinity to the Forssman antigen (N-acetylgalactosamine(GalNAc)alpha1-3GalNAcbeta1-3Galalpha1-4Galbeta1-4Glc-ceram ide), and the presence of Forssman antigen-like sugar on the surface of Symbiodinium CS-156 cells was previously confirmed. Here we report the crystal structures of SLL-2 and its GalNAc complex as the first crystal structures of a lectin involved in the symbiosis between coral and dinoflagellate. N-Linked sugar chains and a galactose derivative binding site common to H-type lectins were observed in each monomer of the hexameric SLL-2 crystal structure. In addition, unique sugar-binding site-like regions were identified at the top and bottom of the hexameric SLL-2 structure. These structural features suggest a possible binding mode between SLL-2 and Forssman antigen-like pentasaccharide. Crystal structure of a symbiosis-related lectin from octocoral.,Kita A, Jimbo M, Sakai R, Morimoto Y, Miki K Glycobiology. 2015 Sep;25(9):1016-23. doi: 10.1093/glycob/cwv033. Epub 2015 May, 28. PMID:26022515 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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