Arginine repressor

spinqualitylabelsall models E. coli structure of arginine repressor C terminal hexamer complex with arginine (PDB entry 1xxb) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Arginine repressor (ArgR) is a prokaryotic repressor which regulates the arginine deiminase pathway. In this pathway, arginine is metabolized to form ammonia, CO2 and ATP. The ArgR releases the expression of the arginine deiminase pathway in the presence of arginine. The genes controlled by ArgR are not found in a single operon. While repressors are usually active as dimers, ArgR is a hexamer and binds to 2 palindromic DNA sites called ARG box in its N terminal domain. Structural highlights The structure of ArgR shows a DNA-binding domain (residues 80-156 in E. coli) at the acidic N-terminal and a basic C-terminal domain which contains the intersubunit interaction sites and the Arg binding site.

3D structures of arginine repressor

Updated on 04-November-2015

{"openlevels":0}

• Arginine repressor
  • 1b4a – GsArgR – Geobacillus stearothermophilus
    
  • 1f9n – BsArgR – Bacillus subtilis
    
  • 3v4g – ArgR – Vibrio vulnificus
    
  • 3ere – MtArgR + DNA – Mycobacterium tuberculosis
    
  • 3fhz, 3laj – MtArgR + DNA + Arg
    
  • 3lap – MtArgR + DNA + canavanine
    
• Arginine repressor N terminal
  • 1aoy – EcArgR N terminal - Escherichia coli - NMR
    
  • 1b4b – BsArgR N terminal
    
  • 2p5l – BsArgR N terminal + DNA
    
• Arginine repressor C terminal
  • 1xxc – EcArgR C terminal
    
  • 2p5k – GsArgR C terminal
    
  • 3bue – MtArgR C terminal
    
  • 1xxa, 1xxb – EcArgR C terminal + Arg
    
  • 2p5m – BsArgR C terminal (mutant) + Arg
    
  • 2zfz, 3cag – MtArgR C terminal + Arg
    

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky