| Arrestin (ARR) is a ubiquitous protein which binds to the G protein-coupled receptor after its phosphorylation. ARR binding blocks further G protein-mediated signaling and redirects signaling to alternative non-G protein-independent pathways. Hence, ARR are versatile adaptor molecules which can also activate signaling cascades and are involved in nuclear functions.
Function
Disease
Relevance
Structural highlights |
3D Structures of arrestin
Updated on 04-November-2015
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- Arrestin-2 (β-arrestin-1)
- 1g4m, 1g4r, 1jsy, 2wtr – bARR2 - bovine
- 1zsh – bARR2 + inositol hexakisphosphate
- 3gc3, 3gd1 – bARR2 + clathrin heavy chain
- 4jqi – rARR2 + antibody + vasopressin V2 receptor peptide - rat
- Arrestin-3 (β-arrestin-2)
- S-arrestin (P44)
- Arrestin-4 or Cone arrestin
- 1suj – ARRC – tiger salamander
References
