Arrestin

spinqualitylabelsall models Bovine arrestin-2 complex with Ba+2 ions (PDB code 2wtr) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Arrestin (ARR) is a ubiquitous protein which binds to the G protein-coupled receptor after its phosphorylation. ARR binding blocks further G protein-mediated signaling and redirects signaling to alternative non-G protein-independent pathways. Hence, ARR are versatile adaptor molecules which can also activate signaling cascades and are involved in nuclear functions. Structural highlights ARR consist of 2 domains. The N terminal domain structure is immunoglobulin-like. The binding site of phosphorylated light-activated rhodopsin is located at the N terminal of ARR.

3D Structures of arrestin

Updated on 04-November-2015

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• Arrestin-2 (β-arrestin-1)
  • 1g4m, 1g4r, 1jsy, 2wtr – bARR2 - bovine
    
  • 1zsh – bARR2 + inositol hexakisphosphate
    
  • 3gc3, 3gd1 – bARR2 + clathrin heavy chain
    
  • 4jqi – rARR2 + antibody + vasopressin V2 receptor peptide - rat
    
• Arrestin-3 (β-arrestin-2)
  • 3p2d – bARR3
    
• S-arrestin (P44)
  • 1ayr, 1cf1, 3ugu, 3ugx, 4j2q – bS-ARR
    
• Arrestin-4 or Cone arrestin
  • 1suj – ARRC – tiger salamander
    

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