Sandbox 420

Cannabinoid Receptor 1

spinqualitylabelsall models Caption for this structure Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Abstract K2 and other newly popularized drugs laced with synthetic cannabinoids, which mimic those found in marijuana, bind similarly to g-coupled receptors found throughout the body and nervous system. CBR1, in particular, is comprised of 472, mostly nonpolar amino acids that fold into a secondary structure consisting of ten alpha helices and one beta pleated sheet forming a transmembrane domain. Binding to endogenous and exogenous ligands alike, CBR1 acts as an activator in a signal transduction pathway to aid in regulating many major bodily systems. You may include any references to papers as in: the use of JSmol in Proteopedia or to the article describing Jmol to the rescue. Structural highlights This is a sample scene created with SAT to color by Group, and another to make a transparent representation of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.