4qkd | pdb_00004qkd

Crystal structure of human ALKBH7 in complex with alpha-ketoglutarate and Mn(II)

spinqualitylabelsall models 4qkd, resolution 1.35Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4qkd is a 3 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: AKG, MN NonStd Res: LED Related: 4qkf, 4qkb Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum Function [ALKB7_HUMAN] Probable dioxygenase required to induce programmed necrosis in response to DNA damage caused by cytotoxic alkylating agents. Acts by triggering the collapse of mitochondrial membrane potential and loss of mitochondrial function that leads to energy depletion and cell death . ALKBH7-mediated necrosis is probably required to prevent the accumulation of cells with DNA damage. Does not display DNA demethylase activity. Involved in fatty acid metabolism. Publication Abstract from PubMed ALKBH7 is the mitochondrial AlkB family member that is required for alkylation- and oxidation-induced programmed necrosis. In contrast to the protective role of other AlkB family members after suffering alkylation-induced DNA damage, ALKBH7 triggers the collapse of mitochondrial membrane potential and promotes cell death From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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OCA, Joel L. Sussman