CD59

spinqualitylabelsall models Structure of human CD59 extracellular domain (green) complex with intermedilysin (cyan) (PDB entry 4bik) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function CD59 (Cluster of Differentiation 59) is a protein which attaches to host cells via a GPI anchor. CD59 can prevent the formation of complement membrane attack complex via binding to complement C8 or C9. Relevance HIV, vaccinia and cytomegalovirus incorporate human CD59 into their envelope thus preventing their lysis by complement. Disease Mutations in CD59 causes disease involving thrombosis. Structural highlights Human CD59 extracellular domain complex with intermedilysin .

3D structures of CD59

Updated on 29-November-2015

1erg, 1erh, 1cdq, 1cdr, 1cds – hCD59 extracellular domain – human - NMR
2ofs, 2j8b, 2uwr, 2ux2 – hCD59 extracellular domain
4bik – hCD59 extracellular domain + intermedilysin

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Michal Harel, Alexander Berchansky