Sandbox 7465
|
DeltaFosB
FIGURE: This is a crystal structure of FosB from Staphylococcus aureus. This is a similar structure to DeltaFosB, although it retains 2 destabilizing elements which are spliced in the DeltaFosB variant. The DeltaFosB transcription factor should include 3 domains: a transactivating domain, a DNA binding domain, and a signal sensing domain. DeltaFosB includes is a basic motif, a Leucine zipper, and a bZIP domain scene
PDB ID: 4NB0 Structure and Function of the Genomically Encoded Fosfomycin Resistance Enzyme, FosB, from Staphylococcus aureus. (2014) Biochemistry 53: 755-765
INTRODUCTION
The transcription factor, DeltaFosB, is known to be involved in some of the physiological mechanisms linked to addiction and compulsive behaviors. Levels of DeltaFosB have been shown to increase in multiple regions of the brain in response to repeated drug exposure as well as stress, certain antipsychotic or antidepressant medications, electroconvulsive seizures, and certain lesions Cite error: Closing </ref> missing for <ref> tag
- ↑ James, K., Ruffle, B. S. (2014) Molecular neurobiology of addiction: what’s all the (∆)FosB about?, The American Journal of Drug and Alcohol Abuse, 40(6), 428-437.
- ↑ Jorissen, H. J., Ulery, P. G., Henry, L., Gourneni, S., Nestler, E. J., & Rudenko, G. (2007) Dimerization and DNA-binding properties of the transcription factor ΔFosB. Biochemistry, 46(28), 8360-8372.x
- ↑ Kelz, M. B., Chen, J., Carlezon, W. A., Whisler, K., Gilden, L., Beckmann, A. M., ... & Nestler, E. J. (1999). Expression of the transcription factor ΔFosB in the brain controls sensitivity to cocaine. Nature, 401(6750), 272-276.x
- ↑ Nestler, E. J. (2008). Transcriptional mechanisms of addiction: role of ΔFosB.Philosophical Transactions of the Royal Society of London B: Biological Sciences, 363(1507), 3245-3255.x
- ↑ Pitchers, K. K., Vialou, V., Nestler, E. J., Laviolette, S. R., Lehman, M. N., & Coolen, L. M. (2013). Natural and drug rewards act on common neural plasticity mechanisms with ΔFosB as a key mediator. The Journal of Neuroscience,33(8), 3434-3442.x
