Cholesterol esterase

Function

Cholesterol esterase (ChoE) also named bile-acid activated lipase catalyzes the hydrolytic cleavage of cholesterol, other sterol esters and triglycerides.

Disease

Deficiency of this enzyme causes Wolman’s disease and cholesteryl ester storage disease.

Structural highlights

ChoE ligand-binding tunnel is ca. 30 A long and has the catalytic triad Ser-His-Glu at the opening and hydrophobic residues lining the bottom cup. </StructureSection>

3D structures of cholesterol esterase

Updated on 07-December-2015

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• Cholesterol esterase
  • 1akn – bChoE – bovine
    
  • 2bce – bChoE (mutant)
    
  • 1jmy – hChoE - human
    
  • 1f6w – hChoE catalytic domain (mutant)
• Cholesterol esterase complex with bile acids
  • 1cle – CcChoE + cholesteryl linoleate – Candida cylindracea
    
  • 1llf – CcChoE + tricosanoic acid
    
  • 1aql – bChoE + taurocholate

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Michal Harel, Alexander Berchansky