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Function
Complexin (CPLX) is the protein which binds the SNARE protein complex with high affinity. CPLX acts as both inhibitor and facilitator of vesicle fusion and neurotransmitter release at the synapse. CPLX clamps SNARE complexes to prevent vesicle fusion while in another conformation it releases the SNARE complex allowing fusion.[1]
Structural highlights
CPLX binds to v-SNARE protein VAMP2 and to t-SNARE proteins SNAP25 and syntaxin (PDB entry 3rk3).[2]
- ↑ Hu K, Carroll J, Rickman C, Davletov B. Action of complexin on SNARE complex. J Biol Chem. 2002 Nov 1;277(44):41652-6. Epub 2002 Aug 27. PMID:12200427 doi:https://dx.doi.org/10.1074/jbc.M205044200
- ↑ Kummel D, Krishnakumar SS, Radoff DT, Li F, Giraudo CG, Pincet F, Rothman JE, Reinisch KM. Complexin cross-links prefusion SNAREs into a zigzag array. Nat Struct Mol Biol. 2011 Jul 24;18(8):927-33. doi: 10.1038/nsmb.2101. PMID:21785414 doi:10.1038/nsmb.2101
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3D structures of complexin
Updated on 20-December-2015
3rk3 – CPLX + SNARE – rat
3rk3, 3rl0 - CPLX + SNARE – human
References
