DAHP synthase

spinqualitylabelsall models E. coli DAHP synthase complex with PEP, phenylalanine, sulfate and Mn+2 ion (PDB code 1fkl) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function DAHP synthase or 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase (DAHPS) catalyzes the conversion of phosphoenolpyruvate (PEP) and D-erythrose 4-phosphate to 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) and phosphate. DAHPS is part of the shikimate pathway. DAHPS requires a bivalent metal ion cofactor for normal activity. DAHPS is a tetramer. DAHPS exhibits feedback inhibition by aromatic amino acids like tyrosine, phenylalanine and tryptophan. Structural highlights The bivalent metal is bound to a Cys-X-X-His motif. The DAHPS active site is located in a channel at the C-terminal of the enzyme where the substrate (PEP), inhibitor (phenylalanine) and the metal ion (Mn+2) are seen.

3D Structures of DAHP synthase

Updated on 21-December-2015

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• DAHP synthase
  • 1vr6 - TmDAHPS – Thermotoga maritima
    
  • 3pg8 - TmDAHPS catalytic domain
    
  • 1ofp - yDAHPS – yeast
    
  • 1ofb, 1ofq - yDAHPS + Mn
    
  • 4uma, 4umb, 4umc - NmDAHPS + Mn – Nisseria meningitidis
    
  • 4ixx - NmDAHPS (mutant) + Mn
    
  • 3tqk - DAHPS + Mn – Francisella tularensis
    
• DAHP synthase binary complex
  • 4hsn - NmDAHPS + Mn + PEP
    
  • 4c1k - PfDAHPS + Cd + PEP – Pyrococcus furiosus
    
  • 1zco - PfDAHPS + Mn + PEP
    
  • 1of6 - yDAHPS + Mn + tyrosine
    
  • 1hfb - yDAHPS + PEP
    
  • 1oab - yDAHPS + Mn + PEP
    
  • 1ofa - yDAHPS + Co + PEP
    
  • 1ofr - yDAHPS + Mn + phenylalanine
    
  • 1og0 - yDAHPS (mutant) + Mn + phenylalanine
    
  • 2b7o - MtDAHPS + Mn + PEP – Mycobacterium tuberculosis
    
  • 3nud - MtDAHPS + phenylalanine
    
  • 2ypo - MtDAHPS + Mn + phenylalanine
    
  • 3nue - MtDAHPS + Mn + tryptophan
    
  • 2ypp - MtDAHPS + Mn + tyrosine
    
  • 3nv8 - MtDAHPS + Mn + PEP
    
  • 3pfp - MtDAHPS + Mn + inhibitor
    
  • 1qr7 - EcDAHPS + Pb + PEP – Escherichia coli
    
  • 1gg1 - EcDAHPS + Mn + phosphoglycolate
    
  • 1n8f – EcDAHPS (mutant) + Mn + PEP
    
  • 1ofo - yDAHPS + phosphoglycolate
  • 1vs1 - DAHPS + Mn + PEP – Aeropyrum pernix
    
  • 2w19 - MtDAHPS + chorismate mutase
    
• DAHP synthase ternary complex
  • 1of8 - yDAHPS + Co + PEP + glycerol-3-phosphate
    
  • 1rzm - TmDAHPS + Cd + PEP + erythrose-4-phosphate
    
  • 3pg9 – TmDAHPS + tyrosine + inhibitor
    
  • 1kfl - EcDAHPS + Mn + PEP + phenylalanine
    
  • 4hso - MnDAHPS (mutant) + Mn + PEP + tyrosine
    
  • 2w1a - MtDAHPS + Mn + TSA + chorismate mutase
    
  • 3kgf, 3rzi - MtDAHPS + Mn + phenylalanine + tryptophan
    
  • 2ypq - MtDAHPS + Mn + tyrosine + tryptophan
    

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