}
| Function
Defensins (DEF) are small cationic defense proteins active against bacteria, fungi and viruses. DEF contains 6-8 conserved cysteine residues. DEF binds to microbial cell membrane forming pores and thus allowing outflow of essential nutrients.[1] For details on plant DEF see Plant defensin.
Relevance
There is increase in α-DEF in chronic inflammations and several cancers.
- ↑ Larsen NA, Turner JM, Stevens J, Rosser SJ, Basran A, Lerner RA, Bruce NC, Wilson IA. Crystal structure of a bacterial cocaine esterase. Nat Struct Biol. 2002 Jan;9(1):17-21. PMID:11742345 doi:10.1038/nsb742
|
3D structures of defensin
Updated on 22-December-2015
{"openlevels":0}
- α-defensin
- Plant defensin – DEFA – Protophormia terraenovae
- 1ews – DEFA RK-1 – rabbit – NMR
- 2k1i - RmDEFA – Rhesus macaque - NMR
- 1zmh, 1zmi, 1zmk - hDEFA HNP-2 (mutant) – human
- 3gny, 3go0, 3hj2 - hDEFA HNP-1
- 2kht - hDEFA HNP-1 - NMR
- 2pm1, 2pm4, 2pm5, 3hjd, 3h6c, 3lo1, 3lo2, 3lo4, 3lo6, 3lo8, 3loe, 3lvx, 4du0, 4lb1, 4lb7, 4lbb, 4lbf - hDEFA HNP-1 (mutant)
- 1zmm – hDEFA4
- 2lew – mDEFA4 (mutant) – mouse – NMR
- 2ley – mDEFA4 – NMR
- 1zmp – hDEFA5
- 2lxz – hDEFA5 – NMR
- 3i5w, 4e82, 4e83, 4e86 – hDEFA5 (mutant)
- 1zmq – hDEFA6
- 3qte – hDEFA6 (mutant)
- β-defensin
- 1iju, 1ijv – hDEFB1
- 2nlb, 2nld, 2nle, 2nlf, 2nlg, 2nlh, 2nlp, 2nlq, 2nls, 2plz, 2lwl, 2nlc - hDEFB1 (mutant)
- 1e4s, 1kj5 – hDEFB1 – NMR
- 1fd3, 1fd4 – hDEFB2
- 1fqq, 1e4q - hDEFB2 – NMR
- 2lg5 - cDEFB2 – chicken – NMR
- 2lg6 - cDEFB2 (mutant) – NMR
- 1kj6 – hDEFB3 – NMR
- 1e4t – mDEFB7 – NMR
- 1e4r - mDEFB8 – NMR
- 1bnb – DEFB12 – bovine – NMR
- ϑ-defensin
- Other defensins
- 1dfn – hDEF HNP-3
- 3lo9 – hDEF1 (mutant)
- 2mit – hDEF5 – NMR
- 1fjn – DEF MGD-1 – Mediterranean mussel
- 1mr4 – tDEF NAD1 – tobacco – NMR
- 4aaz, 4ab0 - tDEF NAD1
- 4cqk - tDEF NAD1 + ligand
- 1ozz – AdDEF ARD1 – Archaeoprepona demophon – NMR
- 1p00, 1p0a - AdDEF ARD1 (mutant) – NMR
- 1ti5 - VrDEF – Vigna radiata – NMR
- 2gl1 – VrDEF2
- 2b68 - DEF – Pacific oyster – NMR
- 2b5b - DEF – Loggerhead turtle – NMR
- 2e3e, 2e3f, 2e3g, 2ny8, 2ny9, 2nz3 - DEF (mutant) – Anopheles – NMR
- 2rng - DEF – Horseshoe crab – NMR
- 3psm – DEF – Potato bean
- 2ksk – DEF5 – Sugarcane - NMR
- 2lj7 – DEF – lentil – NMR
- 2lr3 – DEF – barrel medic – NMR
References
