Defensin

spinqualitylabelsall models Humanα-defensin 1 (PDB entry 2pm4) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Defensins (DEF) are small cationic defense proteins active against bacteria, fungi and viruses. DEF are found in cells of the immune system. DEF binds to microbial cell membrane forming pores and thus allowing outflow of essential nutrients thus killing them. For details on plant DEF see Plant defensin. Relevance There is increase in α-DEF in chronic inflammations and several cancers. DEF-mimetics are developed as antibiotics. Disease Overexpression of α-defensin is seen in chronic inflammation, several cancers and in T-cells of schizophrenia patients. Structural highlights DEF contains 6-8 conserved cysteine residues.

3D structures of defensin

Updated on 22-December-2015

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• α-defensin
  • Plant defensin – DEFA – Protophormia terraenovae
    
  • 1ews – DEFA RK-1 – rabbit – NMR
    
  • 2k1i - RmDEFA – Rhesus macaque - NMR
    
  • 1zmh, 1zmi, 1zmk - hDEFA HNP-2 (mutant) – human
    
  • 3gny, 3go0, 3hj2 - hDEFA HNP-1
    
  • 2kht - hDEFA HNP-1 - NMR
    
  • 2pm1, 2pm4, 2pm5, 3hjd, 3h6c, 3lo1, 3lo2, 3lo4, 3lo6, 3lo8, 3loe, 3lvx, 4du0, 4lb1, 4lb7, 4lbb, 4lbf - hDEFA HNP-1 (mutant)
    
  • 1zmm – hDEFA4
    
  • 2lew – mDEFA4 (mutant) – mouse – NMR
    
  • 2ley – mDEFA4 – NMR
    
  • 1zmp – hDEFA5
    
  • 2lxz – hDEFA5 – NMR
    
  • 3i5w, 4e82, 4e83, 4e86 – hDEFA5 (mutant)
    
  • 1zmq – hDEFA6
    
  • 3qte – hDEFA6 (mutant)
• β-defensin
  • 1iju, 1ijv – hDEFB1
    
  • 2nlb, 2nld, 2nle, 2nlf, 2nlg, 2nlh, 2nlp, 2nlq, 2nls, 2plz, 2lwl, 2nlc - hDEFB1 (mutant)
    
  • 1e4s, 1kj5 – hDEFB1 – NMR
    
  • 1fd3, 1fd4 – hDEFB2
    
  • 1fqq, 1e4q - hDEFB2 – NMR
    
  • 2lg5 - cDEFB2 – chicken – NMR
    
  • 2lg6 - cDEFB2 (mutant) – NMR
    
  • 1kj6 – hDEFB3 – NMR
    
  • 1e4t – mDEFB7 – NMR
    
  • 1e4r - mDEFB8 – NMR
    
  • 1bnb – DEFB12 – bovine – NMR
    
• ϑ-defensin
  • 1hvz – RmDEF1 – NMR
    
• Other defensins
  • 1dfn – hDEF HNP-3
    
  • 3lo9 – hDEF1 (mutant)
    
  • 2mit – hDEF5 – NMR
    
  • 1fjn – DEF MGD-1 – Mediterranean mussel
    
  • 1mr4 – tDEF NAD1 – tobacco – NMR
    
  • 4aaz, 4ab0 - tDEF NAD1
    
  • 4cqk - tDEF NAD1 + ligand
    
  • 1ozz – AdDEF ARD1 – Archaeoprepona demophon – NMR
    
  • 1p00, 1p0a - AdDEF ARD1 (mutant) – NMR
    
  • 1ti5 - VrDEF – Vigna radiata – NMR
    
  • 2gl1 – VrDEF2
    
  • 2b68 - DEF – Pacific oyster – NMR
    
  • 2b5b - DEF – Loggerhead turtle – NMR
    
  • 2e3e, 2e3f, 2e3g, 2ny8, 2ny9, 2nz3 - DEF (mutant) – Anopheles – NMR
    
  • 2rng - DEF – Horseshoe crab – NMR
    
  • 3psm – DEF – Potato bean
    
  • 2ksk – DEF5 – Sugarcane - NMR
    
  • 2lj7 – DEF – lentil – NMR
    
  • 2lr3 – DEF – barrel medic – NMR
    

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Michal Harel, Alexander Berchansky