Ficolin

spinqualitylabelsall models Human H-ficolin binding domain trimer complex with Ca+2 ion (PDB code 2j64) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Ficolin (Fic) are defense proteins which belong to the innate immune system and recognize carbohydrate molecules. 3 ficolins were identified in humans L-Fic, H-Fic and M-Fic.

3D Structures of Ficolin

Updated on 22-January-2016

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• H-ficolin
  • 2j64 - hH-Fic binding domain - human
    
  • 2j5z - hH-Fic binding domain + galactose
    
  • 2j60 - hH-Fic binding domain + fucose
    
  • 2j61 - hH-Fic binding domain + acetyl-glucosamine
    
• L-ficolin
  • 2j3g, 4r9t - hL-Fic binding domain
    
  • 2j0g – hL-Fic binding domain + N-acetyl-mannosamine
    
  • 2j0h - hL-Fic binding domain + acetylcholine
    
  • 4nyt - hL-Fic binding domain + phosphocholine
    
  • 2j0y - hL-Fic binding domain + glucan
    
  • 2j1g, 2j2p - hL-Fic binding domain + acetylcysteine
    
  • 2j3f - hL-Fic binding domain + galactosamine
    
  • 2j3o - hL-Fic binding domain + acetyl-glucosamine
    
  • 4r9j - hL-Fic binding domain + glucosamine sulfate
    
  • 2j3u - hL-Fic binding domain + galactose
    
• M-ficolin
  • 2d39 – hM-Fic fibrinogen-like domain
    
  • 2wnp - hM-Fic fibrinogen-like domain (mutant)
    
  • 2jhh, 2jhm – hM-Fic C terminal
    
  • 2jhi - hL-Mic C terminal + acetyl-galactosamine
    
  • 2jhk - hL-Mic C terminal + acetyl-glucosamine
    
  • 2jhl - hL-Mic C terminal + sialic acid

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Michal Harel, Alexander Berchansky