Filamin

File:3hop.png

Crystal structure of Human Filamin A complex with phosphate, 3hop

spinqualitylabelsall models Human Filamin B actin-binding domain complex with sulfate and carbonate (PDB code 2wa5) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Filamin A (FLNA) has an actin-binding domain (ABD). It crosslinks actin filaments and participates in anchoring of membrane proteins. Filamin B (FLNB) is a human cytoplasmic protein which functions similarly to FLNA and guides proper skeletal development. Filamin C (FLNC) is functionally similar and contains 3 domains: the N-terminal ABD, the C-terminal dimerization domain (DD) and a membrane glycoprotein-binding domain. For more details on filamin C see Group:MUZIC:FilaminC. Disease Mutations in FLNA cause frontometaphyseal dysplasia, intestinal pseudo-obstruction, Melnick-Needles syndrome, otopalatodigital syndrome and periventricular heterotopia. Mutations in FLNAB cause boomerang dysplasia.

3D structures of filamin

Updated on 22-January-2016

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• Filamin A
  • 3isw – hFLNA repeat 21+CFTR peptide – human
    
  • 3rgh - hFLNA repeat 10
    
  • 2wfn, 3hop, 3hor – hFLNA ABD
    
  • 3hoc – hFLNA ABD (mutant)
    
  • 4m9p - hFLNA domains 3-5
    
  • 2aav - hFLNA domain 17 – NMR
    
  • 2bp3 - hFLNA domain 17+GPIB peptide
    
  • 2k7p – hFLNA domains 16-17
    
  • 2k7q - hFLNA domains 18-19
    
  • 2j3s - hFLNA domains 19-21
    
  • 2w0p - hFLNA domain 21+migfilin peptide
    
  • 2jf1, 2brq - hFLNA domain 21+integrin peptide
    
  • 2k3t - hFLNA domain 23 – NMR
    
  • 3cnk - hFLNA DD
    
• Filamin B
  • 2wa5, 3fer - hFLNB ABD
    
  • 2wa6, 2wa7, 4b7l - hFLNB ABD (mutant)
    
  • 2di9, 2dia, 2dib, 2dic, 2dj4, 2e9j, 2dmb, 2ee9, 2ee7, 2dmc, 2di8, 2dlg, 2e9i, 2ee6, 2eeb, 2eec, 2eed - hFLNB domains 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 20, 21, 22, 23, 24 – NMR
    
  • 2eea - hFLNB domain 17 – NMR
    
• Filamin C
  • 2k9u – hFLNC+migfilin peptide
    
  • 2d7m, 2d7n, 2d7o, 2d7p - hFLNC domains 14, 16, 17, 22 - NMR
    
  • 2nqc - hFLNC domain 21
    
  • 2d7q - hFLNC domain 23 – NMR
    
  • 3v8o - hFLNC domains 4,5
    
  • 4mgx - hFLNC domains 4,5 + platelet glycoprotein peptide
    
  • 1v05 - hFLNC DD
    
• Other Filamins
  • 1wlh, 1qfh – FLN rod domain – Dictyostelium discoideum
    

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Alexander Berchansky, Jaime Prilusky, Michal Harel