Lysin

egg lysin

spinqualitylabelsall models Abalone lysin )PDB code 1lis) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Egg Lysin, a protein from abalone sperm, creates a hole in the envelope of the egg, permitting the sperm to pass through the envelope and fuse with the egg. Structural highlights The structure of lysin, refined at 1.9 angstroms resolution, reveals an alpha-helical, amphipathic moleculeTo see alpha helixes press here. you can see the alpha helixes in pink. the surface of the protein exhibits three features: two tracks of basic residues that span the length of the molecule, a solvent-exposed cluster of aromatic and aliphatic amino acids,(in green) and an extended amino-terminal hypervariable domain that is species-specific. The structure suggests possible mechanisms of action.

References

The crystal structure of lysin, a fertilization protein. Shaw A1, McRee DE, Vacquier VD, Stout CD.

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Carmit Ginesin, Michal Harel, Alexander Berchansky, Jaime Prilusky, Joel L. Sussman