2dsi | pdb_00002dsi

Crystal structure of Glu171 to Arg mutant of Diphthine synthase

spinqualitylabelsall models 2dsi, resolution 2.20Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 2dsi is a 2 chain structure with sequence from Pyrho. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: GOL, MES, SAH, SO4 Related: 1wng, 2dsg, 2dsh Gene: dphB (PYRHO) Activity: Diphthine synthase, with EC number 2.1.1.98 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, TOPSAN Function [DPHB_PYRHO] S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. See Also Diphthine synthase

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