3kx2 | pdb_00003kx2

Crystal structure of Prp43p in complex with ADP

spinqualitylabelsall models 3kx2, resolution 2.20Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3kx2 is a 2 chain structure with sequence from Baker's yeast. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: ADP, MG Gene: YGL120C (Baker's yeast) Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum Function [PRP43_YEAST] Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMed DEAH helicases participate in pre-messenger RNA splicing and ribosome biogenesis. The structure of yeast Prp43p-ADP reveals the homology of DEAH helicases to DNA helicases and the presence of an oligonucleotide-binding motif. A beta-hairpin from the second RecA domain is wedged between two carboxy-terminal domains and blocks access to the occluded RNA binding site formed by the RecA domains and a C-terminal domain. ATP binding and hydrolysis are likely to induce conformational changes in the hairpin that are important for RNA unwinding or ribonucleoprotein remodelling. The structure of Prp43p provides the framework for functional and genetic analysis of all DEAH helicases. Structural basis for the function of DEAH helicases.,He Y, Andersen GR, Nielsen KH EMBO Rep. 2010 Mar;11(3):180-6. Epub 2010 Feb 19. PMID:20168331 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Helicase Pre-mRNA-splicing factor

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