2jh8 | pdb_00002jh8

THE STRUCTURE OF BLUETONGUE VIRUS VP4 REVEALS A MULTIFUNCTIONAL RNA-CAPPING PRODUCTION-LINE

spinqualitylabelsall models 2jh8, resolution 3.22Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 2jh8 is a 1 chain structure with sequence from Bluetongue virus 10 (isolate usa). Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: GUN, M7G Related: 2jh9, 2jha, 2jhc Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum Function [VP4_BTV10] The VP4 protein is one of the five proteins (with VP1, VP3, VP6 and VP7) which form the inner capsid of the virus. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMed Eukaryotic organisms cap the 5' ends of their messenger RNAs by a series of four chemical reactions. Some viruses achieve this using a single molecule; the crystal structure of such an enzyme from bluetongue virus reveals an elongated modular architecture that provides a scaffold for an assemblage of active sites, two contributed by a domain of novel structure. Bluetongue virus VP4 is an RNA-capping assembly line.,Sutton G, Grimes JM, Stuart DI, Roy P Nat Struct Mol Biol. 2007 May;14(5):449-51. Epub 2007 Apr 8. PMID:17417654 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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