1cwf | pdb_00001cwf
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| 1cwf, resolution 1.86Å | |||||||||||||
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| Sites: | BIN | ||||||||||||
| Ligands: | BMT, DAL, MLE, MVA, SAR | ||||||||||||
| Gene: | CYCLOPHILIN (Homo sapiens) | ||||||||||||
| Activity: | Peptidylprolyl isomerase, with EC number 5.2.1.8 | ||||||||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
HUMAN CYCLOPHILIN A COMPLEXED WITH 2-VAL CYCLOSPORIN
Overview
Eight new X-ray structures of different cyclophilin A/cyclosporin-derivative complexes are presented. These structures, combined with the existing three published cyclosporin complexes, provide a useful structural database for the analysis of protein-ligand interactions. The effect of small chemical differences on protein-ligand hydrogen-bonding, van der Waals interactions and water structure is presented.
About this Structure
1CWF is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
X-ray structures and analysis of 11 cyclosporin derivatives complexed with cyclophilin A., Kallen J, Mikol V, Taylor P, Walkinshaw MD, J Mol Biol. 1998 Oct 23;283(2):435-49. PMID:9769216
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