3g05 | pdb_00003g05

Crystal structure of N-terminal domain (2-550) of E.coli MnmG

spinqualitylabelsall models 3g05, resolution 3.49Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3g05 is a 2 chain structure with sequence from Escherichia coli 0157:h7 edl933. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: SO4 Related: 3ces Gene: ECs4683, gidA, mnmG, Z5241 (Escherichia coli 0157:H7 EDL933) Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, TOPSAN Function [MNMG_ECO57] NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMed The MnmE-MnmG complex is involved in tRNA modification. We have determined the crystal structure of Escherichia coli MnmG at 2.4-A resolution, mutated highly conserved residues with putative roles in flavin adenine dinucleotide (FAD) or tRNA binding and MnmE interaction, and analyzed the effects of these mutations in vivo and in vitro. Limited trypsinolysis of MnmG suggests significant conformational changes upon FAD binding. Structure-function analysis of Escherichia coli MnmG (GidA), a highly conserved tRNA-modifying enzyme.,Shi R, Villarroya M, Ruiz-Partida R, Li Y, Proteau A, Prado S, Moukadiri I, Benitez-Paez A, Lomas R, Wagner J, Matte A, Velazquez-Campoy A, Armengod ME, Cygler M J Bacteriol. 2009 Dec;191(24):7614-9. Epub 2009 Oct 2. PMID:19801413 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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