2w7y | pdb_00002w7y

STRUCTURE OF A STREPTOCOCCUS PNEUMONIAE SOLUTE-BINDING PROTEIN IN COMPLEX WITH THE BLOOD GROUP A-TRISACCHARIDE.

spinqualitylabelsall models 2w7y, resolution 2.35Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 2w7y is a 2 chain structure with sequence from Streptococcus pneumoniae sp3-bs71. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: IOD, A2G, FUC, GAL NonStd Res: MSE Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMed Streptococcus pneumoniae is a common bacterial pathogen that is well known for its ability to cause acute respiratory disease (pneumonia), ear infections, and other serious illnesses. This Gram-positive bacterium relies on its carbohydrate-metabolizing capabilities for full virulence in its host; however, the range of glycan targets that it can attack is presently not fully appreciated. S. pneumoniae is known to have a fucose utilization operon that in the TIGR4 strain plays a role in its virulence. Here we identify a second type of fucose utilization operon that is present in a subset of S. pneumoniae strains, including the serotype 3 strain SP3-BS71. This operon contains a transporter with a solute-binding protein, FcsSBP (fucose solute-binding protein), that interacts tightly (Ka approximately 1 x 10(6) M(-1)) and specifically with soluble A- and B-antigen trisaccharides but displays no selectivity between these two sugars. The structure of the FcsSBP in complex with the A-trisaccharide antigen, determined to 2.35 A, reveals its mode of binding to the reducing end of this sugar, thus highlighting this protein's requirement for soluble blood group antigen ligands. Overall, this report exposes a heretofore unknown capability of certain S. pneumoniae strains to transport and potentially metabolize the histo-blood group antigen carbohydrates of its host. Blood group antigen recognition by a solute-binding protein from a serotype 3 strain of Streptococcus pneumoniae.,Higgins MA, Abbott DW, Boulanger MJ, Boraston AB J Mol Biol. 2009 May 1;388(2):299-309. Epub 2009 Mar 12. PMID:19285508 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also ABC transporter

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