Fibrin

spinqualitylabelsall models Fibrinα1 subunit (red, yellow), β subunit (cyan, blue), γ subunit (orange, magenta) from Petromyzon marinus (PDB entry 1n73) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Fibrin (or Factor Ia, FIa) is a fibrous protein which when polymerized is involved in blood clotting. The polymerization epitopes of FIa are called A-knob and B-knob. Fibrinogen (Factor I, FI) is converted by thrombin to fibrin. Limited proteolysis of FI results in a fragment named D which when cross-linked by factor XIII is called double-D FIa (DDFIa). Disease Overexpression of FIa can cause thrombosis. Structural highlights Ca coordination site in β subunit. Ca coordination site in γ subunit (PDB entry 1n73).

3D Structures of Fibrin

Updated on 21-February-2016

Fibrinogen – hFIa peptide+ hFI α, β, γ chains – human
1n73, 2z4e - hFIa B-knob+ hFI α, β, γ chains
2hlo, 1n86 - hFIa α, β, γ chains + peptide
1n8e - hFIa α, β, γ chains
1n73 - FIa α, β, γ chains + peptide – Sea lamprey
1fzc – hDDFIa+peptide

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Alexander Berchansky, Michal Harel