Sandbox Reserved 429

This Sandbox is Reserved from January 19, 2016, through August 31, 2016 for use for Proteopedia Team Projects by the class Chemistry 423 Biochemistry for Chemists taught by Lynmarie K Thompson at University of Massachusetts Amherst, USA. This reservation includes Sandbox Reserved 425 through Sandbox Reserved 439.

Penicillin binding protein/lactivicin (inhibitor) (2jch)

by Tyler Carpenter, Samuel Pierce, Hyunjoon Choi, Anton El Khoury and Tiankai Zhang

Student Projects for UMass Chemistry 423 Spring 2016

Introduction

spinqualitylabelsall models 2jch, Saves cells from dying since the appearance of life Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D

Outline: 1) Why is it important? Penicillin-binding proteins are essential for cell wall biogenesis. General info about bacterial cell wall biogenesis. Also, how bacteria mutate in order to avoid binding to beta-lactam. 2) Ligands, in particular phenoxyacetyl lactivicin. Also, how PBP binds lactivicin. Sample green scene: Penicillin-binding protein has four ligands, one of which is the electron-deficient olefin ligand or EDO

Overall Structure

spinqualitylabelsall models 2jch, insert caption here Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D

Binding Interactions

spinqualitylabelsall models 2jch, Insert caption here Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D

Additional Features

spinqualitylabelsall models 2jch, Insert caption here Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D

Quiz Question 1

spinqualitylabelsall models 2jch, Insert caption here Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D

See Also

• Penicillin-binding protein
• 2y2g
• 2bg1
• 2fff
• 2jch

Credits

Introduction - name of team member

Overall Structure - name of team member

Drug Binding Site - name of team member

Additional Features - name of team member

Quiz Question 1 - name of team member