4yia | pdb_00004yia

Structural mechanism of hormone release in thyroxine binding globulin

spinqualitylabelsall models 4yia, resolution 1.58Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4yia is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: CA, CL, IMN, NA Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum Disease [THBG_HUMAN] Defects in SERPINA7 are a cause of thyroxine-binding globulin deficiency (TBG deficiency) [MIM:314200]. Mutations in the SERPINA7 gene can result as a whole spectrum of deficiencies, characterized by either reduced or increased TBG levels in the serum. Patients show, respectively, reduced or elevated protein-bound iodine but are euthyroid. Function [THBG_HUMAN] Major thyroid hormone transport protein in serum.

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