4zjc | pdb_00004zjc

Structures of the human OX1 orexin receptor bound to selective and dual antagonists

spinqualitylabelsall models 4zjc, resolution 2.83Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4zjc is a 1 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: 4OT, OLA Related: 4zj8 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum Function [OX1R_HUMAN] Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Seems to be exclusively coupled to the G(q) subclass of heteromeric G proteins, which activates the phospholipase C mediated signaling cascade (By similarity).

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