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Human metabotropic glutamate receptor 5 transmembrane domain

spinqualitylabelsall models Human metabotropic glutamate receptor 5 transmembrane domain Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D The Human metabotropic glutamate receptor 5 transmembrane domain is a Structure Figure Legend Ionic Locks This is the Ionic Lock in inactive state. Structural highlights This is a sample scene created with SAT to color by Group, and another to make a transparent representation of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

References

1.Clemmensen, C., Smajilovic, S., Wellendorph, P., and Brauner-Osborne, H. (2013). “The GPCR, class C, group 6, subtype A (GPCR6A) receptor: from cloning to physiological function.” British Journal of Pharmacology. 171: 1129-41. 2. Dore, Andrew S., Okrasa, Krzysztof, Okrasa., Patel,, Jayesh, C., Serrano-Vega, Maria., Bennett, Kirstie., Cooke, Robert M., Errey, James C., Jazayeri, Ali., Khan, Samir., Tehan, Ben., Weir, Malcolm., Wiggin, Giselle R., Marshall, Fiona H. (2014) “Structure of class C GPCR metabotropic glutamate receptor 5 transmembrane domain.” Nature. 511: 557-62. 3.Feng, Zhiwei, Shifan Ma, Guanxing Hu, and Xiang-Qun Xie.(2015). "Allosteric Binding Site and Activation Mechanism of Class C G-Protein Coupled Receptors: Metabotropic Glutamate Receptor Family." The AAPS Journal AAPS J 17.3 (2015): 737-53. 4Niswender, Colleen M., and P. Jeffrey Conn.(2010). "Metabotropic Glutamate Receptors: Physiology, Pharmacology, and Disease." Annu. Rev. Pharmacol. Toxicol. Annual Review of Pharmacology and Toxicology 50.1: 295-322. Web. 5"Novartis Announces Results of Mavoglurant (mGluR5) (AFQ056) Clinical Trials and the Conclusion of the Long-Term Extension Study" (2014). NFXF. Foward, 24 Apr. Web. 6. Wu, Huixian, Wang, Chong, Gregory, Karen J., Han, Gye W., Cho, Hyekyung P., Xia, Yan, Niswender, Colleen M., Katritch, Vsevolod, Meiler, Jens, Cherezov, Vadim, Conn, P.J., Stevens, Raymond C. (2014) “Structure of class C GPCR metabotropic glutamate receptor 1 Bound to an Allosteric Modulator.” Science. 344: 58-64. 7. Woodcook, Elizabeth A., Kistler, Peter M., Ju, Yue-Kun. (2009) “Phosphoinositide signalling and cardiac arrhythmias.” European Society of Cardiology. 82: 286-95. 8."4009."(2014). Structure of the Human Class C GPCR Metabotropic Glutamate Receptor 5 Transmembrane Domain in Complex with the Negative Allosteric Modulator Mavoglurant. RCSB PDB, n.d. Web. 22 Feb. 2016

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Cutter J. Koehler