Gp41

Function

Gp41 is a subunit of the envelope protein of retrovirus. Gp41 is a transmembrane protein and contains several sites which are involved in the infection of the host cells. Gp160 is the cleavable precursor of Gp41 and Gp120. For more details see Hiv env proteins.

Relevance

Fusion inhibitory drugs which bind to Gp41 prevent the attachment of the ~HIV-1 virus to the cell.

3D Structures of Gp41

Updated on 16-March-2016

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• Gp41 from HIV-1
  • 1aik – Gp41
    
  • 1env, 3k9a – Gp41 (mutant)
    
  • 1szt – Gp41 thermostable domain
    
  • 3cp1, 3cyo – Gp41 thermostable domain (mutant)
    
  • 1df4, 1df5, 1qr8, 1qr9, 1dlb, 1jpx – Gp41 core
    
  • 1f23, 1k33, 1k34, 1i5x, 1i5y, 2ot5 – Gp41 core (mutant)
    
  • 2z2t, 2zzo, 3aha, 3vie, 2r3c, 2r5b, 2r5d, 3l36, 3l37, 3vgy, 3vh7, 3vtp, 3vu5, 3vu6 – Gp41 N-heptad repeat + Gp41 fusion inhibitor peptide
    
  • 2zfc – Gp41 N-peptide
    
  • 4i2l – Gp41 N-peptide (mutant)
    
  • 3u91 – Gp41 N-terminal
    
  • 4hlr – Gp41 N-terminal (mutant)
    
  • 3o3x – arGp41 - artificial
    
  • 4dzu – arGp41 + 3-α
    
  • 4dzv – arGp41 + 4-α/β
    
• Gp41 from Simian Immunodeficiency Virus
  • 2siv – Gp41 core
    
  • 2ezo, 2ezp, 2ezq, 2ezr, 2ezs, 1qce – Gp41 core - NMR
    
  • 1qbz, 1jq0 – Gp41 core (mutant)
    

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky