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<math></math>==Human GPR40, also known as Free Fatty Acid Receptor 1 (FFAR1)==

spinqualitylabelsall models hGPR40 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Background Human G-protein coupled receptor 40 (hGPR40) is a seven helical transmembrane domain receptor for long-chain free fatty acids that slimutates insulin secretion (Srivastava). This enzyme is primarily located in the pancreatic b-cells in the islets of Langerhans, and as such, it has become a target for potential Type II Diabetes treatments (Kebede). Activation of hGPR40 has been shown to both stimulate insulin secretion and decrease glucose concentration (Ma, 2016). GPR40 is a member of a group of homologous GPCRs all located on chromosome 19q13.1 including GPR41, 42, and 43. Structure Figure Legend seven transmembrane helices top view of TM helices Binding Sites Tak-875 Binding Site Figure 2. Second proposed binding site of GPR40. By visual inspection, a second possible binding site was proposed between transmembrane helices 3, 4, and 5 on the intracellular side. Figure 3. Third proposed binding site of GPR40. By visual inspection, a third possible binding site was proposed between transmembrane helices 1, 2, and 7 on the extracellular side. ECL2 beta sheet Clinical Relevance Tak-875 Figure Legend Tak-875