Lactoferrin

spinqualitylabelsall models Humanα-defensin 1 (PDB entry 2pm4) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Lactoferrin (LTF) is found in secretory fluids. It is a component of the immune system and has antimicrobial activity. LTF interacts with DNA, RNA, polysaccharides and heparin. For detailed discussion of human lactoferrin see Human lactoferrin. Relevance LTF is inhibited by nonsteroidal anti-inflammatory drugs (NSAID) like aspirin.

3D Structures of lactoferrin

Updated on 10-April-2016

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• Apo lactoferrin
  • Human lactoferrin, 1b7u – hoLTF – horse
    
  • 1dtz – cLTF - camel
    
  • 1cb6, 1lfg, 1lfh – hLTF - human
    
  • 1u62, 1xv4, 1xv7, 1z6v, 1z6w - hLTF peptide – NMR
    
  • 1lfc – bLTF residues 17-41 – bovine – NMR
    
  • 1y58, 1y5c - bLTF residues 4-14 – NMR
    
  • 4oqo – bLTF C lobe
    
• Lactoferrin
  • 1blf – bLTF + 2Fe
    
  • 1sdx - bLTF C lobe + 3Zn
    
  • 1nkx, 3u8q - bLTF C lobe + 2Zn + Fe
    
  • 1b1x, 1f9b – hoLTF + 2Fe
    
  • 1qjm – hoLTF + 2Sm
    
  • 1ce2, 1biy – buLTF + 2Fe - buffalo
    
  • 1i6q – cLTF + 2Fe
    
  • 2bjj, 1sqy, 1n76– hLTF + 2Fe
    
  • 1b0l - hLTF (mutant) + 2Fe
    
  • 1fck – hLTF + 2Ce
    
  • 1lfi - hLTF + 2Cu
    
  • 1lct - hLTF N lobe + 2Fe
    
  • 1h43, 1h44, 1h45, 1l5t, 1eh3, 1vfd, 1vfe, 1hse, 1dsn - hLTF N lobe (mutant) + 2Fe
    
  • 1jw1 – LTF + 2Fe – goat
• Lactoferrin binary complex
  • 3sdf – bLTF C lobe + lipoteichoic acid + 2Zn + Fe
    
  • 4n6p - bLTF C lobe + meclofenamic acid + 2Zn + Fe
    
  • 4ned - bLTF C lobe + fenoprofen + 2Zn + Fe
    
  • 3rgy - bLTF C lobe + lipopolysaccharide + Zn + Fe
    
  • 3kj7, 3k0v, 2q8j, 2o51, 2nwj, 2dxy, 2dwj, 2dsf, 2ds9, 2hca, 2dqv, 2dp8, 2g93, 2ays, 2alu, 2dwi, 2dyx, 2o1l, 2p1s - bLTF C lobe + polysaccharide + 2Zn + Fe
    
  • 2o1l - bLTF C lobe + polysaccharide + Zn + Fe
    
  • 2fa7, 2b65 - bLTF C lobe + polysaccharide + 3Zn + Fe
    
  • 2dvc, 2dwa, 2dwh, 2e0s, 2e1s, 2h4i, 2px1 - bLTF C lobe + saccharide + 2Zn + Fe
    
  • 2dxr - bLTF C lobe + sorbitol+ 2Zn + Fe
    
  • 3iaz, 3ib0, 3ib1 - bLTF C lobe (mutant) + NSAID + 2Zn + Fe
    
  • 3e9x, 2qje, 2zmb, 3crb, 2nuv, 4fim, 4fjp, 4for, 4g2z, 4g77, 4g8h, 4grk, 3taj - bLTF C lobe + NSAID + 2Zn + Fe
    
  • 3o97, 3mjn, 3cfl, 2ocu, 3tod, 3tus – bLTF C lobe + inhibitor + 2Zn + Fe
    
  • 3ib2 - bLTF C lobe (mutant) + inhibitor + 2Zn + Fe
    
  • 2doj - bLTF C lobe + adenosine + 2Zn + Fe
    
  • 3ugw - bLTF C lobe + deoxycytidine + 2Zn + Fe
    
  • 3ci8 - bLTF C lobe + niacin + 2Zn + Fe
    
  • 2r9j - bLTF C lobe + nicotinamide + 2Zn + Fe
    
  • 2r71 - bLTF C lobe + inositol + 2Zn + Fe
    
  • 3uk4 - bLTF C lobe + pentatriol + 2Zn + Fe
    
  • 3usd - bLTF C lobe + pyridine derivative + 2Zn + Fe
    
  • 3ttr - bLTF C lobe + anasthetic + 2Zn + Fe
    
  • 3vdf - bLTF C lobe + diaminopimelic acid + 2Zn + Fe
    
  • 4dxu - bLTF C lobe + caproic acid + 2Zn + Fe
    
  • 3v5a - bLTF C lobe + γ-amino butyric acid + 2Zn + Fe
    
  • 3u72, 4dig - bLTF C lobe + polypeptide + 2Zn + Fe
    
  • 3ptl – bLTF peptide + proteinase K
    
  • 1bjr - buLTF peptide + proteinase K
    
  • 1b7z - hoLTF + 2Fe + oxalate
    
  • 3cr9 – hoLTF + inhibitor + 2Fe
    
  • 2j4u – cLTF N terminal + OMPC
    
  • 1bka - hLTF + 2Fe + oxalate
    
  • 1lcf - hLTF + 2Cu + oxalate
    
  • 2pms – hLTF N lobe + PSPA transferring-binding domain + 2Zn + 2Fe
    

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