Lactoferrin

spinqualitylabelsall models Human lactoferrin complex with oxalate and Fe+3 ion (PDB entry 1bka) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Lactoferrin (LTF) is found in secretory fluids. LTF interacts with DNA, RNA, polysaccharides and heparin. For detailed discussion of human lactoferrin see Human lactoferrin. Relevance LTF is inhibited by nonsteroidal anti-inflammatory drugs (NSAID) like aspirin. It is a component of the immune system and has antimicrobial activity. Structural highlights LTF is a bilobal protein with the N-terminal half and the C-terminal half called N-lobe and C-lobe. LTF binds with high affinity Fe+3 ion and an anion in both its N-lobe and its C-lobe. The binding site is between the 2 domains of each lobe. The anion binds the Fe+3 in a 1,2 bidendate fashion.

3D Structures of lactoferrin

Updated on 10-April-2016

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• Apo lactoferrin
  • Human lactoferrin, 1b7u – hoLTF – horse
    
  • 1dtz – cLTF - camel
    
  • 1cb6, 1lfg, 1lfh – hLTF - human
    
  • 1u62, 1xv4, 1xv7, 1z6v, 1z6w - hLTF peptide – NMR
    
  • 1lfc – bLTF residues 17-41 – bovine – NMR
    
  • 1y58, 1y5c - bLTF residues 4-14 – NMR
    
  • 4oqo – bLTF C lobe
    
• Lactoferrin
  • 1blf – bLTF + 2Fe
    
  • 1sdx - bLTF C lobe + 3Zn
    
  • 1nkx, 3u8q - bLTF C lobe + 2Zn + Fe
    
  • 1b1x, 1f9b – hoLTF + 2Fe
    
  • 1qjm – hoLTF + 2Sm
    
  • 1ce2, 1biy – buLTF + 2Fe - buffalo
    
  • 1i6q – cLTF + 2Fe
    
  • 2bjj, 1sqy, 1n76– hLTF + 2Fe
    
  • 1b0l - hLTF (mutant) + 2Fe
    
  • 1fck – hLTF + 2Ce
    
  • 1lfi - hLTF + 2Cu
    
  • 1lct - hLTF N lobe + 2Fe
    
  • 1h43, 1h44, 1h45, 1l5t, 1eh3, 1vfd, 1vfe, 1hse, 1dsn - hLTF N lobe (mutant) + 2Fe
    
  • 1jw1 – LTF + 2Fe – goat
• Lactoferrin binary complex
  • 3sdf – bLTF C lobe + lipoteichoic acid + 2Zn + Fe
    
  • 4n6p - bLTF C lobe + meclofenamic acid + 2Zn + Fe
    
  • 4ned - bLTF C lobe + fenoprofen + 2Zn + Fe
    
  • 3rgy - bLTF C lobe + lipopolysaccharide + Zn + Fe
    
  • 3kj7, 3k0v, 2q8j, 2o51, 2nwj, 2dxy, 2dwj, 2dsf, 2ds9, 2hca, 2dqv, 2dp8, 2g93, 2ays, 2alu, 2dwi, 2dyx, 2o1l, 2p1s - bLTF C lobe + polysaccharide + 2Zn + Fe
    
  • 2o1l - bLTF C lobe + polysaccharide + Zn + Fe
    
  • 2fa7, 2b65 - bLTF C lobe + polysaccharide + 3Zn + Fe
    
  • 2dvc, 2dwa, 2dwh, 2e0s, 2e1s, 2h4i, 2px1 - bLTF C lobe + saccharide + 2Zn + Fe
    
  • 2dxr - bLTF C lobe + sorbitol+ 2Zn + Fe
    
  • 3iaz, 3ib0, 3ib1 - bLTF C lobe (mutant) + NSAID + 2Zn + Fe
    
  • 3e9x, 2qje, 2zmb, 3crb, 2nuv, 4fim, 4fjp, 4for, 4g2z, 4g77, 4g8h, 4grk, 3taj - bLTF C lobe + NSAID + 2Zn + Fe
    
  • 3o97, 3mjn, 3cfl, 2ocu, 3tod, 3tus – bLTF C lobe + inhibitor + 2Zn + Fe
    
  • 3ib2 - bLTF C lobe (mutant) + inhibitor + 2Zn + Fe
    
  • 2doj - bLTF C lobe + adenosine + 2Zn + Fe
    
  • 3ugw - bLTF C lobe + deoxycytidine + 2Zn + Fe
    
  • 3ci8 - bLTF C lobe + niacin + 2Zn + Fe
    
  • 2r9j - bLTF C lobe + nicotinamide + 2Zn + Fe
    
  • 2r71 - bLTF C lobe + inositol + 2Zn + Fe
    
  • 3uk4 - bLTF C lobe + pentatriol + 2Zn + Fe
    
  • 3usd - bLTF C lobe + pyridine derivative + 2Zn + Fe
    
  • 3ttr - bLTF C lobe + anasthetic + 2Zn + Fe
    
  • 3vdf - bLTF C lobe + diaminopimelic acid + 2Zn + Fe
    
  • 4dxu - bLTF C lobe + caproic acid + 2Zn + Fe
    
  • 3v5a - bLTF C lobe + γ-amino butyric acid + 2Zn + Fe
    
  • 3u72, 4dig - bLTF C lobe + polypeptide + 2Zn + Fe
    
  • 3ptl – bLTF peptide + proteinase K
    
  • 1bjr - buLTF peptide + proteinase K
    
  • 1b7z - hoLTF + 2Fe + oxalate
    
  • 3cr9 – hoLTF + inhibitor + 2Fe
    
  • 2j4u – cLTF N terminal + OMPC
    
  • 1bka - hLTF + 2Fe + oxalate
    
  • 1lcf - hLTF + 2Cu + oxalate
    
  • 2pms – hLTF N lobe + PSPA transferring-binding domain + 2Zn + 2Fe
    

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