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spinqualitylabelsall models 7TM structure of human class B GPCR 4L6R Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D

Ligand Binding Interactions and Crucial Disulfide Bond

Glucagon Binding Zoomed Out

Glucagon Binding Zoomed Out

Glucagon Binding Full Rendering

Glucagon Binding Zoomed in

Old Stuff:

Fig. 1: A135P Mutation and effect on stalk stability .

Fig. 2: Stalk stabilized by salt bridge between Glu133-Lys136. Residues in yellow are demonstrated to have an effect on ligand binding affinity.

Fig. 3: Active sites linked to glucagon binding affinity located on ECL1 are labeled.

Fig. 4: Corticotropin-releasing factor 1 and glucagon receptors; Class B GPCRs with notable central splay

Fig. 5: Beta 2-adrenergic (class A) and glucagon receptors; showing an absence of central splay in Class A GPCRs.

Fig. 7: Active site buried deep in 7TMD of glucagon receptor.

Fig. 9: Location of anchoring pocket within central cavity.

Fig. 10: Ballooned pocket functioning as anchoring site for glucagon residues 1-4.