Netrin receptor

spinqualitylabelsall models Glycosylated human netrin receptor DCC fibronectin type V-VI domains (green) complex with neutrin-1 (grey), sulfate, Ca+2 and Cl-1 ions (PDB code 4urt) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Netrin receptors are cell surface proteins which bind netrins. Netrins direct cell and axon migration during development. Netrin attraction is mediated through DCC (Deleted in Colorectal Cancer) receptors while netrin repulsion is mediated through the UNC-5 receptor. Structural highlights Netrin DCC receptor extracellular domain contains 4 Ig repeats followed by 6 type III fibronectin repeats. Netrin UNC-5 receptor extracellular domain contains 2 Ig repeats followed by 2 type I thrombospondin repeats.

3D Structures of netrin receptor

Updated on 08-May-2016

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• Netrin receptor DCC
  • 2ed7 – hDCC first fibronectin type III domain – human - NMR
    
  • 2ed8 – hDCC second fibronectin type III domain - NMR
    
  • 2ed9 – hDCC third fibronectin type III domain - NMR
    
  • 2edb – hDCC fourth fibronectin type III domain - NMR
    
  • 2edd – hDCC fifth fibronectin type III domain - NMR
    
  • 2ede – hDCC sixth fibronectin type III domain - NMR
    
  • 3au4 – hDCC P3 motif + myosin-X
    
  • 4urt – hDCC fibronectin type V-VI domains + neutrin-1
    
  • 4plo – mDCC fourth fibronectin type IV domain + neutrin-1 - mouse
    
  • 3pzd – mDCC P3 motif + myosin-X
    
• Netrin receptor UNC5A
  • 4v2a – hUNC5A ectodomain
    
• Netrin receptor UNC5H2
  • 1wmg – mUNC5H2 death domain
    

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Michal Harel