| Structural highlights
5fzo is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
| | Ligands: | CL, EDO, MN |
| NonStd Res: | CSD |
| Related: | 5fym, 5fys, 5fyt, 5fyu, 5fyv, 5fyy, 5fyz, 5fz0, 5fz1, 5fz3, 5fz4, 5fz6, 5fz7, 5fz8, 5fz9, 5fza, 5fzb, 5fzc, 5fzd, 5fze, 5fzf, 5fzg, 5fzh, 5fzi, 5fzk, 5fzl, 5fzm |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum |
Function
[JHD2C_HUMAN] Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes (By similarity).
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