Template:STRUCTURE 1f5v
Function
Nitroreductase (NR) is involved in the reduction of nitrogen-containing compounds including those containing NO2 group. The NO2 group is reduced to hydroxylamine[1]. NR uses FMN as cofactor. Among NRs are the oxygen-insensitive NAD(P)H NR and NADH dehydrogenase.
Relevance
The NR is of special interest due to its potential use as activator of prodrugs in cancer therapy.
3D structures of nitroreductase
Updated on 15-May-2016
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- Nitroreductase
- 1f5v, 1oo5 – EcNR – Escherichia coli
- 3bm1, 1ds7 – EcNR minimal
- 3bm2 – EcNR minimal -FMN
- 1nec, 1kqd – EclNR – Enterobacter cloacae
- 1ywq, 2i7h – NR – Bacillus cereus
- 2b67 – NR – Streptococcus pneumonia
- 3ek3, 3hoi – NR – Bacterioides fragilis
- 3g14 – NR – Clostridium novyi
- 3h4o, 3koq - NR – Clostridium difficile
- 3gr3 – NR – Bartonella henselae
- 3hzn – NR – Salmonella typhimurium
- 3k6h – NR – Agrobacterium tumefaciens
- 2wzv, 2ymv – MsNR – Mycobacterium smegmatis
- 3of4 – NR FMN/FAD – Idiomarina loihiensis
- 3n2s – NR – Bacillus subtilis
- 3pxv – NR – Desulfitobacterium hafniense
- 3qdl – NR – Helicobacter pylori
- 3r5l, 3r5p - MtNR – Mycobacterium tuberculosis
- 3r5r, 3r5w – MtNR F420
- 3ge6 – NR – Exiguobacterium sibiricum
- 4dn2 – NR – Geobacter metallireducens
- Copper-induced nitroreductase
- 2wqf – LlNR – Lactococcus lactis
- 4bn6 – LlNR + chloramphenicol
- 4bn7, 4bn8 – LlNR + phenol derivative
- 4bn9 – LlNR + nicotinic acid
- 4bnb – LlNR + nitroquinoline
- Nitroreductase binary complex
- ↑ Lovering AL, Hyde EI, Searle PF, White SA. The structure of Escherichia coli nitroreductase complexed with nicotinic acid: three crystal forms at 1.7 A, 1.8 A and 2.4 A resolution. J Mol Biol. 2001 May 25;309(1):203-13. PMID:11491290 doi:10.1006/jmbi.2001.4653
References
