Template:STRUCTURE 1nsk
Nucleoside diphosphate kinase (NDK) catalyzes the exchange of phosphate between nucleoside triphosphate and nucleoside diphosphate. This reaction is a multi-step reaction which is used for the synthesis of nucleoside triphosphates other than ATP[1]. NDK provides nucleoside triphosphates for nucleic acid synthesis, CTP for lipid synthesis, UTP for polysaccharide synthesis and GTP for protein elongation, signal transduction and microtubule polymerization.
3D structures of nucleoside diphosphate kinase
Updated on 06-June-2016
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- Nucleoside diphosphate kinase
- 1ndk, 1npk, 1s5z – DdNDK – Dictyostelium discoideum
- 1nlk, 1nsp - DdNDK with phosphohistidine intermediate
- 1leo, 1ncl, 1hlw, 1hhq, 1pae, 4c6a - DdNDK (mutant)
- 2nck – MxNDK – Myxococcus xanthus
- 1ndl – DmNDK – Drosophila melanogaster
- 1nsq - DmNDK with phosphohistidine intermediate
- 1nsk, 1jxv, 3l7u, 4eno - hNDK A – human
- 1ehw - hNDK 4 (mutant)
- 3bbc - hNDK B (mutant)
- 1k44, 4anc – MtNDK – Mycobacterium tuberculosis
- 4and, 4ane - MtNDK (mutant)
- 1nb2 - NDK - Virgibacillus halodenitrificans
- 1xiq - NDK A – Plasmodium falciparum
- 1w7w - NDK – pea
- 1u8w - AtNDK I – Arabidopsis thaliana
- 1s57 - AtNDK II
- 1pku - NDK I – rice
- 1wkj - TtNDK – Thermus thermophilus
- 1xqi - NDK (mutant) – Pyrobaculum aerophilum
- 2az1 - HsNDK – Halobacterium salinarum
- 2hur - NDK – Escherichia coli
- 3b54 - NDK – yeast
- 2vu5 - NDK – Bacillus anthracis
- 2zua - NDK – Haloarcula quadrata
- 3mpd - NDK – Encephalitozoon cuniculi
- 3pj9 - NDK – Campylobacter jejuni
- 3r9l - NDK – Giardia lamblia
- 3ngr, 3ngs - LmNDK – Leishmania major
- 3prv - NDK – Trypanosoma cruzi
- 3q83 - SaNDK – Staphylococcus aureus
- 4di6 - BbNDK – Borrelia burgdorferi
- 3ztq, 3zto, 3ztp, 3ztr, 3zts - NDK – Aquifex aeolicus
- 4dut - BtNDK – Burkholderia thailandensis
- 2cwk - PhNDK – Pyrococcus horikoshii
- 3vgs, 3vgt - HaNDK – Halomonas
- 3vgu, 3vgv - HaNDK (mutant)
- 3vvt - NDK – reconstructed archaeal ancestral
- 3vvu - NDK – reconstructed bacterial ancestral
- 4f36 – TbNDK – Trypanosoma brucei
- NDK complex with adenine derivative
- NDK complex with thymidine derivative
- 1f3f - DdNDK (mutant) + TDP derivative + TTP derivative
- 1lwx - DdNDK (mutant) + azido-TDP
- 1f6t - DdNDK + TDP derivative
- 1mn7 - DdNDK (mutant) + TTP derivative
- 1ndc - DdNDK + TDP
- 3ddi - ApNDK (mutant) + TDP – Acanthamoeba polyphaga
- 3em1, 3evw, 3fbc, 3fbf, 3g2x, 3evo - ApNDK (mutant) + TDP derivative
- NDK complex with cytosine derivative
- NDK complex with guanine derivative
- 1nue , 3bbf - hNDK + GDP
- 1s59 - AtNDK + GDP derivative + GTP derivative
- 3bbb - hNDK B + GMP derivative + AMP derivative
- 1wkk - TtNDK + GDP
- 2dxe - PhNDK + GDP
- 2dxf - PhNDK + GTP analog
- 3gp9 - ApNDK + GDP
- 3b6b - ApNDK + GDP derivative
- 3fbe, 3dkd, 3ejm - ApNDK (mutant) + GDP
- 3emt, 3ena - ApNDK (mutant) + GDP derivative
- 3q86 - SaNDK + GTP
- NDK complex with uridine derivative
- 1b99 - DdNDK + UDP derivative
- 3eic - ApNDK + UDP
- 3elh - ApNDK + UDP derivative
- 3fbb, 3fcv - ApNDK (mutant) + UDP derivative
- 3fcw - ApNDK (mutant) + UDP
- 3q8v - SaNDK + UDP
- 4f4a - TbNDK + UDP
- NDK complex with antiviral drug
- 1mn9, 3fkb - DdNDK (mutant) + antiviral drug
- ↑ Chen Y, Gallois-Montbrun S, Schneider B, Veron M, Morera S, Deville-Bonne D, Janin J. Nucleotide binding to nucleoside diphosphate kinases: X-ray structure of human NDPK-A in complex with ADP and comparison to protein kinases. J Mol Biol. 2003 Sep 26;332(4):915-26. PMID:12972261
