Function
Nucleoside diphosphate kinase (NDK) catalyzes the exchange of phosphate between nucleoside triphosphate and nucleoside diphosphate. This reaction is a multi-step reaction which is used for the synthesis of nucleoside triphosphates other than ATP[1]. NDK provides nucleoside triphosphates for nucleic acid synthesis, CTP for lipid synthesis, UTP for polysaccharide synthesis and GTP for protein elongation, signal transduction and microtubule polymerization.
Disease
NDKB deficiency causes diabetes-like vascular pathology[2].
3D structures of nucleoside diphosphate kinase
Updated on 06-June-2016
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- Nucleoside diphosphate kinase
- 1ndk, 1npk, 1s5z – DdNDK – Dictyostelium discoideum
- 1nlk, 1nsp - DdNDK with phosphohistidine intermediate
- 1leo, 1ncl, 1hlw, 1hhq, 1pae, 4c6a - DdNDK (mutant)
- 2nck – MxNDK – Myxococcus xanthus
- 1ndl – DmNDK – Drosophila melanogaster
- 1nsq - DmNDK with phosphohistidine intermediate
- 1nsk, 1jxv, 3l7u, 4eno - hNDK A – human
- 1ehw - hNDK 4 (mutant)
- 3bbc - hNDK B (mutant)
- 1k44, 4anc – MtNDK – Mycobacterium tuberculosis
- 4and, 4ane - MtNDK (mutant)
- 1nb2 - NDK - Virgibacillus halodenitrificans
- 1xiq - NDK A – Plasmodium falciparum
- 1w7w - NDK – pea
- 1u8w - AtNDK I – Arabidopsis thaliana
- 1s57 - AtNDK II
- 1pku - NDK I – rice
- 1wkj - TtNDK – Thermus thermophilus
- 1xqi - NDK (mutant) – Pyrobaculum aerophilum
- 2az1 - HsNDK – Halobacterium salinarum
- 2hur - NDK – Escherichia coli
- 3b54 - NDK – yeast
- 2vu5 - NDK – Bacillus anthracis
- 2zua - NDK – Haloarcula quadrata
- 3mpd - NDK – Encephalitozoon cuniculi
- 3pj9 - NDK – Campylobacter jejuni
- 3r9l - NDK – Giardia lamblia
- 3ngr, 3ngs - LmNDK – Leishmania major
- 3prv - NDK – Trypanosoma cruzi
- 3q83 - SaNDK – Staphylococcus aureus
- 4di6 - BbNDK – Borrelia burgdorferi
- 3ztq, 3zto, 3ztp, 3ztr, 3zts - NDK – Aquifex aeolicus
- 4dut - BtNDK – Burkholderia thailandensis
- 2cwk - PhNDK – Pyrococcus horikoshii
- 3vgs, 3vgt - HaNDK – Halomonas
- 3vgu, 3vgv - HaNDK (mutant)
- 3vvt - NDK – reconstructed archaeal ancestral
- 3vvu - NDK – reconstructed bacterial ancestral
- 4f36 – TbNDK – Trypanosoma brucei
- NDK complex with adenine derivative
- NDK complex with thymidine derivative
- 1f3f - DdNDK (mutant) + TDP derivative + TTP derivative
- 1lwx - DdNDK (mutant) + azido-TDP
- 1f6t - DdNDK + TDP derivative
- 1mn7 - DdNDK (mutant) + TTP derivative
- 1ndc - DdNDK + TDP
- 3ddi - ApNDK (mutant) + TDP – Acanthamoeba polyphaga
- 3em1, 3evw, 3fbc, 3fbf, 3g2x, 3evo - ApNDK (mutant) + TDP derivative
- NDK complex with cytosine derivative
- NDK complex with guanine derivative
- 1nue , 3bbf - hNDK + GDP
- 1s59 - AtNDK + GDP derivative + GTP derivative
- 3bbb - hNDK B + GMP derivative + AMP derivative
- 1wkk - TtNDK + GDP
- 2dxe - PhNDK + GDP
- 2dxf - PhNDK + GTP analog
- 3gp9 - ApNDK + GDP
- 3b6b - ApNDK + GDP derivative
- 3fbe, 3dkd, 3ejm - ApNDK (mutant) + GDP
- 3emt, 3ena - ApNDK (mutant) + GDP derivative
- 3q86 - SaNDK + GTP
- NDK complex with uridine derivative
- 1b99 - DdNDK + UDP derivative
- 3eic - ApNDK + UDP
- 3elh - ApNDK + UDP derivative
- 3fbb, 3fcv - ApNDK (mutant) + UDP derivative
- 3fcw - ApNDK (mutant) + UDP
- 3q8v - SaNDK + UDP
- 4f4a - TbNDK + UDP
- NDK complex with antiviral drug
- 1mn9, 3fkb - DdNDK (mutant) + antiviral drug
- ↑ Chen Y, Gallois-Montbrun S, Schneider B, Veron M, Morera S, Deville-Bonne D, Janin J. Nucleotide binding to nucleoside diphosphate kinases: X-ray structure of human NDPK-A in complex with ADP and comparison to protein kinases. J Mol Biol. 2003 Sep 26;332(4):915-26. PMID:12972261
- ↑ Qiu Y, Zhao D, Butenschon VM, Bauer AT, Schneider SW, Skolnik EY, Hammes HP, Wieland T, Feng Y. Nucleoside diphosphate kinase B deficiency causes a diabetes-like vascular pathology via up-regulation of endothelial angiopoietin-2 in the retina. Acta Diabetol. 2016 Feb;53(1):81-9. doi: 10.1007/s00592-015-0752-x. Epub 2015 Apr, 23. PMID:25900369 doi:https://dx.doi.org/10.1007/s00592-015-0752-x
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