Template:STRUCTURE 2yz8
Obscurin (Obs) or KIAA1556 is a giant sarcomeric signalling protein expressed in striated muscles. Other giant proteins in the family include titin and nebulin. It is a multidomain protein containing adhesion modules and signaling domains. These domains include: 68 Ig domains, 2 fibronectin domains, 1 calcium/calmodulin-binding domain, 1 RhoGEF domain with PH domain and 2 serine/thereonine kinase domains.
Obscurin binds small ankyrin 1 which is part of the sarcoplasmic reticulum membrane. It associates with the contractile apparatus via binding to titin and sarcomeric myosin. Obscurin is assumed to play a key role in modulating the organization and assembly of sarcomeric reticulum and the myofibril[1].
For more details see Group:MUZIC:Obscurin.
3D structures of obscurin
07-June-2016
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- Obscurin
- 2e7b - hObs 6th Ig domain residues 8-97 – human - NMR
- 2dm7 - hObs 14th Ig domain residues 1157-1251 – NMR
- 2gqh - hObs 15th Ig domain residues 1253-1346 – NMR
- 2eny - hObs Ig domain residues 2735-2825 – NMR
- 2edf - hObs 2nd Ig domain residues 2826-2915 – NMR
- 2dku - hObs Ig domain residues 2915-3004 – NMR
- 2cr6 - hObs Ig domain residues 2998-3100 – NMR
- 2yz8 - hObs 32nd Ig domain residues 3184-3273
- 2edr - hObs Ig domain residues 3361-3449 – NMR
- 2edt - hObs Ig domain residues 3449-3537 – NMR
- 2edw - hObs I-set domain residues 3537-3630 – NMR
- 2edh – hObs PDZ domain residues 3614-3713 – NMR
- 2edq - hObs Ig domain residues 3713-3806 – NMR
- 2edl - hObs Ig domain residues 3801-3897 – NMR
- 1v1c - hObs SH3 domain residues 5601-5668 – NMR
- Obscurin-like protein 1
- 2e6q - hObsL Ig domain residues 615-713 – NMR
- 2e6p - hObsL Ig domain residues 714-804 – NMR
- 3knb, 2wp3, 2wwm, 4c4k – hObs N terminal residues 1-105 + titin M10 domain
- 4uow - hObs residues 26829-26925+ titin M10 domain
- 2wwk – hObs N terminal residues 1-105 (mutant) + titin M10 domain
- ↑ Kontrogianni-Konstantopoulos A, Catino DH, Strong JC, Sutter S, Borisov AB, Pumplin DW, Russell MW, Bloch RJ. Obscurin modulates the assembly and organization of sarcomeres and the sarcoplasmic reticulum. FASEB J. 2006 Oct;20(12):2102-11. PMID:17012262 doi:10.1096/fj.06-5761com
References
