Paired box protein

spinqualitylabelsall models Structure of human PAX-6 complex with DNA (PDB code 6pax). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Paired box protein (PAX) are transcription factors which contain paired box domain and a paired-type homeodomain (60 amino acid helix-turn-helix). • PAX-6 contain 2 DNA-binding domains. It is a regulatory factor in eye and brain development. • PAX-5 is associated with B-cell differentiation. • PAX-3 regulates cell fate in C. elegans • PAX-8 is associated with thyroid follicular cell development and expression of thyroid-specific genes. Disease Mutations in PAX-6 are associated with aniridia and Peter’s anomaly. Mutations in PAX-3 are associated with Waardenburg syndrome, craniofacial-deafness-hand syndrome and alveolar rhabdomyosarcoma.

3D Structures of paired box protein

Updated on 14-June-2016

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• PAX-6
  • 6pax – hPAX + DNA - human
    
  • 2cue – hPAX homeodomain – NMR
    
• PAX-5
  • 1mdm, 1k78 – hPAX paired domain + mETS1 ETS domain + MB-1 promoter DNA
    
• PAX-3
  • 3cmy – hPAX homeodomain – NMR
    
• PAX-8
  • 2k27 – hPAX paired domain - NMR
    

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Michal Harel, Alexander Berchansky