5jvx | pdb_00005jvx

X-ray structure of the adduct formed in the reaction between thaumatin and a gold carbene compound

spinqualitylabelsall models 5jvx, resolution 1.70Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5jvx is a 1 chain structure with sequence from Thaumatococcus daniellii. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: 6O0, CL, TLA Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [THM1_THADA] Taste-modifying protein; intensely sweet-tasting. It is 100000 times sweeter than sucrose on a molar basis. Publication Abstract from PubMed The X-ray structure of the adduct formed in the reaction between the gold N-heterocyclic carbene compound Au(NHC)Cl (with NHC = 1-butyl-3-methyl-imidazole-2-ylidene) and the model protein thaumatin is reported here. The structure reveals binding of Au(NHC)+ fragments to distinct protein sites. Notably, binding of the gold compound occurs at lysine side chains and at the N-terminal tail; the metal binds the protein after releasing Cl- ligand, but retaining NHC fragment. First Crystal Structure for a Gold Carbene-Protein Adduct.,Ferraro G, Gabbiani C, Merlino A Bioconjug Chem. 2016 Jul 6. PMID:27364343 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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