5a5j | pdb_00005a5j

Cytochrome 2C9 P450 inhibitor complex

spinqualitylabelsall models 5a5j, resolution 2.90Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5a5j is a 1 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: 6YF, HEM Related: 5a5i Activity: Cholesterol 25-hydroxylase, with EC number 1.14.99.38 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [CP2C9_HUMAN] Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenytoin, tolbutamide and losartan.

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