3zn4 | pdb_00003zn4

VP16, a capsid protein of bacteriophage P23-77 (VP16-type-2)

spinqualitylabelsall models 3zn4, resolution 1.26Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3zn4 is a 1 chain structure with sequence from Thermus phage p23-77. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: CIT, CL Related: 3zmn, 3zmo, 3zn5, 3zn6 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed It has proved difficult to classify viruses unless they are closely related since their rapid evolution hinders detection of remote evolutionary relationships in their genetic sequences. However, structure varies more slowly than sequence, allowing deeper evolutionary relationships to be detected. Bacteriophage P23-77 is an example of a newly identified viral lineage, with members inhabiting extreme environments. We have solved multiple crystal structures of the major capsid proteins VP16 and VP17 of bacteriophage P23-77. They fit the 14 A resolution cryo-electron microscopy reconstruction of the entire virus exquisitely well, allowing us to propose a model for both the capsid architecture and viral assembly, quite different from previously published models. The structures of the capsid proteins and their mode of association to form the viral capsid suggest that the P23-77-like and adeno-PRD1 lineages of viruses share an extremely ancient common ancestor. Bacteriophage p23-77 capsid protein structures reveal the archetype of an ancient branch from a major virus lineage.,Rissanen I, Grimes JM, Pawlowski A, Mantynen S, Harlos K, Bamford JK, Stuart DI Structure. 2013 May 7;21(5):718-26. doi: 10.1016/j.str.2013.02.026. Epub 2013 Apr, 25. PMID:23623731 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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