3w6j | pdb_00003w6j

Crystal structure of ScpAB core complex

spinqualitylabelsall models 3w6j, resolution 2.60Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3w6j is a 6 chain structure with sequence from Atcc 12980. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Related: 3w6k Gene: scpA (ATCC 12980), scpB (ATCC 12980) Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed In many bacteria, a homodimer of structural-maintenance-of-chromosomes proteins associates with two regulatory subunits (known as ScpA and ScpB), assembling a protein complex that plays a crucial role in chromosome organization and segregation. It remains poorly understood, however, how this complex might work at the mechanistic level. Here, we report crystal structures of the ScpAB core complex that display a highly unusual structure in which the central segment of ScpA winds around an asymmetrically oriented ScpB dimer. The two C-terminal domains of the ScpB dimer primarily interact with different regions of ScpA with different affinities. Moreover, flexible interdomain regions of ScpB contribute to a dynamic folding process of the ScpAB subcomplex. Together with other genetic and biochemical assays, we provide evidence that internal structural changes of the ScpAB subcomplex are tightly coupled with activation of the structural-maintenance-of-chromosomes ATPase. Molecular Basis of SMC ATPase Activation: Role of Internal Structural Changes of the Regulatory Subcomplex ScpAB.,Kamada K, Miyata M, Hirano T Structure. 2013 Mar 26. pii: S0969-2126(13)00057-9. doi:, 10.1016/j.str.2013.02.016. PMID:23541893 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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