4in0 | pdb_00004in0

Crystal Structure of human splicing factor dim2/TXNL4B

spinqualitylabelsall models 4in0, resolution 1.33Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4in0 is a 2 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: SUC Gene: DIM2, DLP, TXNL4B (HUMAN) Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [TXN4B_HUMAN] Essential role in pre-mRNA splicing. Required in cell cycle progression for S/G(2) transition. Publication Abstract from PubMed TXNL4A (thioredoxin-like 4A) is an essential protein conserved from yeast to humans and is a component of the pre-mRNA splicing machinery. TXNL4B was identified as a TXNL4-family protein that also interacts with Prp6, an integral component of the U4/U6.U5 tri-snRNP complex, and has been shown to function in pre-mRNA splicing. A crystal structure of TXNL4B was determined at 1.33 A resolution and refined to an Rwork of 0.13 and an Rfree of 0.18 with one native dimer in the asymmetric unit. Residues 1-33 of TXNL4B have previously been reported to be responsible for its interaction with Prp6. However, this region extends to the beta-sheet core of the thioredoxin-fold structure of TXNL4B. This suggests that the interpretation of the previously reported GST pull-down results without considering the structure and stability of TXNL4B is debatable. High-resolution crystal structure of human Dim2/TXNL4B.,Jin T, Guo F, Wang Y, Zhang Y Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Mar 1;69(Pt 3):223-7. doi:, 10.1107/S1744309113000973. Epub 2013 Feb 22. PMID:23519793 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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